Four new dammarane-type triterpenes derivatives from hydrolyzate of total Gynostemma pentaphyllum saponins and their bioactivities. Issue 11 (3rd June 2019)

• Record Type: Journal Article
• Authors: Zhang, Xiaoshu; Shi, Guohui; Liu, Mingbing; Chen, Rong; Wu, Xiaojun; Zhao, Yuqing
• Is Part Of: Natural product research. Volume 33:Issue 11(2019)
• Page Start: 1605
• Page End: 1611
• Publication Date: 2019-06-03
• Subjects: Gynostemma pentaphyllum -- anti-hepatic fibrosis -- Cardiomyocytes oxidative injury; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1428592
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Phytochemical investigation of hydrolysate of total G. pentaphyllum saponins led to the isolation of four novel triterpenes, Gypensapogenin U (1 ), Gypensapogenin V (2 ), Gypensapogenin W (3 ) and Gypensapogenin X (4 ). The structures of these compounds were identified by 1D, 2D-NMR and HR-ESI-MS evidences. Additionally, the protective activity of these new compounds against cardiomyocytes injury induced by H2 O2 and their cytotoxic activity against t-HSC/Cl-6 cells were evaluated. Abstract :