New cytotoxic natural products from the mangrove biome: covering the period 2007–2015. Issue 11 (3rd June 2019)

• Record Type: Journal Article
• Authors: Pejin, Boris; Glumac, Miodrag
• Is Part Of: Natural product research. Volume 33:Issue 11(2019)
• Page Start: 1624
• Page End: 1628
• Publication Date: 2019-06-03
• Subjects: Mangroves -- organic compounds -- cancer; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1425854
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Nowadays, the mangrove biome is considered to be a profound resource of natural products usually possessing cytotoxicity of a broader range. Covering the period 2007–2015, a total of 21 new naturally occurring compounds has stood out. For example, xylogranin B and swietephragmin C were found to exhibit very potent cytotoxic activity against the colon HCT-116 cells reaching IC50 values of 0.05 and 0.06 μM, respectively. Bearing in mind the efficacy of the majority compounds in the preliminary in vitro screens, these studies should be expanded to both ex vivo and in vivo screens including the evaluation of the relevant toxicological profiles. Abstract :