New 2-arylbenzofurans from the root bark of Artocarpus gomezianus and their α-glucosidase inhibitory activity. Issue 10 (19th May 2019)

• Record Type: Journal Article
• Authors: Nuntawong, Poomraphie; Kongkatitham, Virunh; Likhitwitayawuid, Kittisak; Mekboonsonglarp, Wanwimon; Sukrong, Suchada; Tanasupawat, Somboon; Sritularak, Boonchoo
• Is Part Of: Natural product research. Volume 33:Issue 10(2019)
• Page Start: 1436
• Page End: 1441
• Publication Date: 2019-05-19
• Subjects: Artocarpus gomezianus -- Moraceae -- 2-arylbenzofuran -- α-glucosidase; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1419238
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new 2-arylbenzofurans, namely 13- O -methyllakoochin B (1 ) and artogomezianin (2 ), were isolated from the root bark of Artocarpus gomezianus, along with six known compounds (3 –8 ). The structures of new compounds were determined by spectroscopic and chemical methods. All of the isolates were evaluated for their α-glucosidase inhibitory activity. Artogomezianin (2 ) and lakoochin A (3 ) exhibited strong α-glucosidase inhibitory activity with IC50 values of 18.25 and 26.19 µM, respectively, as compared with the positive control acarbose. Abstract :