Nucleoside alkaloids with anti-platelet aggregation activity from the rhizomes of Ligusticum striatum. Issue 10 (19th May 2019)

• Record Type: Journal Article
• Authors: Pu, Zhong-Hui; Liu, Juan; Peng, Cheng; Luo, Min; Zhou, Qin-Mei; Xie, Xiao-Fang; Chen, Ming-Hua; Xiong, Liang
• Is Part Of: Natural product research. Volume 33:Issue 10(2019)
• Page Start: 1399
• Page End: 1405
• Publication Date: 2019-05-19
• Subjects: Ligusticum striatum -- nucleoside -- alkaloids -- adenosine derivatives -- anti-platelet aggregation activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1416382
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new (1 –2 ) and six known (3 –8 ) nucleoside alkaloids were isolated from the rhizomes of Ligusticum striatum DC. Compounds1 and2 (liguadenosines A and B) were unusual N-10 substituted adenosine derivatives. Their structures were elucidated by extensive spectroscopic analyses and ECD calculation. Most of them significantly inhibited the abnormal increase in platelet aggregation induced by ADP at concentrations of 50 and 100 μM. Particularly, the inhibitory effect of3 was equivalent to aspirin. Abstract :