Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation. (4th July 2019)

• Record Type: Journal Article
• Authors: Demarco, Benjamin; Chen, Kaiwen W.; Broz, Petr
• Is Part Of: Molecular & cellular oncology. Volume 6:Number 4(2019)
• Publication Date: 2019-07-04
• Subjects: Apoptosis -- inflammation -- Gasdermins -- NLRP3 inflammasome -- pannexin; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2019.1610324
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Apoptosis can promote inflammation by triggering activation of the NLRP3 inflammasome (NLR family, pyrin domain containing 3). However, the molecular mechanisms regulating these processes are ill-defined. We recently reported that pannexin-1 is required to promote NLRP3 inflammasome assembly. We further demonstrate that differential cleavage of gasdermin D (GSDMD) by apoptotic caspases regulates inflammatory cell lysis. Here, we discuss our findings and perspectives for future studies.