Complex I and MDM2: hit me baby one more time. (4th July 2019)
- Record Type:
- Journal Article
- Title:
- Complex I and MDM2: hit me baby one more time. (4th July 2019)
- Main Title:
- Complex I and MDM2: hit me baby one more time
- Authors:
- Chipuk, Jerry Edward
- Abstract:
- ABSTRACT: MDM2 (mouse double minute 2) functions as both a tumor suppressor and oncogene, yet little is known if MDM2 regulates cancer cell biology by altering cellular metabolism. We recently found that MDM2 binds NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1), a key protein involved in Complex I assembly, function, and efficiency. The MDM2⋅NDUFS1 interaction promotes reactive oxygen species production, DNA damage, and apoptosis.
- Is Part Of:
- Molecular & cellular oncology. Volume 6:Number 4(2019)
- Journal:
- Molecular & cellular oncology
- Issue:
- Volume 6:Number 4(2019)
- Issue Display:
- Volume 6, Issue 4 (2019)
- Year:
- 2019
- Volume:
- 6
- Issue:
- 4
- Issue Sort Value:
- 2019-0006-0004-0000
- Page Start:
- Page End:
- Publication Date:
- 2019-07-04
- Subjects:
- Apoptosis -- Complex I -- MDM2 -- mitochondria -- NDUFS1
Tumors -- Periodicals
Neoplasms
Periodicals
616.99 - Journal URLs:
- http://www.tandfonline.com/loi/kmco20#.VyIIeFL2aic ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/23723556.2019.1607457 ↗
- Languages:
- English
- ISSNs:
- 2372-3556
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 10686.xml