Autophagy represses hepatic carcinogenesis. (4th July 2019)

• Record Type: Journal Article
• Authors: Paillet, Juliette; Kroemer, Guido
• Is Part Of: Molecular & cellular oncology. Volume 6:Number 4(2019)
• Publication Date: 2019-07-04
• Subjects: Age-related disease -- cytotoxic T cells -- NK cells -- immunosenescence -- senescence; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2019.1573080
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Hepatocyte-specific knockout of the essential autophagy gene Autophagy-related 7 ( Atg7) is sufficient to cause hepatic carcinogenesis. A recent paper by Lee et al. unveils the molecular pathway accounting for hepatic hypertrophy and hyperplasia followed by malignant transformation. This pathway involves the overactivation of the transcription factor yes-associated protein (YAP), which turns out to be an autophagic substrate. Of note, the transcriptional signature activated in mouse hepatocytes lacking Atg7 resembles that found in non-alcoholic steatohepatitis (NASH), as well as in the steatohepatitic subtype of human hepatocellular carcinomas.