Major terpenoids from Telekia speciosa flowers and their cytotoxic activity in vitro. Issue 12 (18th June 2019)

• Record Type: Journal Article
• Authors: Stojakowska, Anna; Galanty, Agnieszka; Malarz, Janusz; Michalik, Marta
• Is Part Of: Natural product research. Volume 33:Issue 12(2019)
• Page Start: 1804
• Page End: 1808
• Publication Date: 2019-06-18
• Subjects: Asperilin -- calenduladiol ester -- cytotoxicity -- Inuleae -- sesquiterpene lactone -- Telekia; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1437431
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: In addition to known constituents of Telekia speciosa, an acetone extract from ray florets of the plant yielded: 5, 5ʹ-dibutoxy-2, 2ʹ-bifuran (1 ), 5, 5ʹ-diisobutoxy-2, 2ʹ-bifuran (2 ), α-tocopherol (3 ), β-tocopherol (4 ), loliolide palmitate (5 ), a mixture of calenduladiol esters - 16β-hydroxylupeol-3-O-palmitate (7 ) and 16β-hydroxylupeol-3-O-myristate (8 ), 1-epiinuviscolide (12 ), inuviscolide (13 ), 3-epiisotelekin (16 ), 4α-hydroxy-9β, 10β-epoxy-1β(H)-11(13)-guaien-8α, 12-olide (17 ), 4α-hydroxy-1β(H)-9(10), 11(13)-guaiadien-8α, 12-olide (18 ), loliolide (19 ) and 4β, 10β-dihydroxy-1α(H), 5α(H)-11(13)-guaien-8α, 12-olide (20 ). Calenduladiol esters and asperilin (14 ) were the major constituents of the extract. Their cytotoxic effect on human normal prostate epithelial cells (PNT-2), human prostate carcinoma cell lines, human skin fibroblasts (HSF) and human melanoma cell lines was examined in vitro . Triterpene esters showed no cytotoxicity against nearly all cell lines tested, except for Du145 prostate carcinoma cells (IC50 – 62.0 μΜ). Asperilin displayed activity against the cell lines under study, especially against three tested lines of melanomas (A375, IC50 – 17.6 μΜ, WM793, IC50 – 28.2 μΜ and Hs 294T, IC50 – 29.5 μΜ). Abstract :