Acetylcholinesterase inhibitory active metabolites from the endophytic fungus Colletotrichum sp. YMF432. Issue 12 (18th June 2019)

• Record Type: Journal Article
• Authors: Li, Zhe; Ma, Ni; Zhao, Pei-Ji
• Is Part Of: Natural product research. Volume 33:Issue 12(2019)
• Page Start: 1794
• Page End: 1797
• Publication Date: 2019-06-18
• Subjects: Huperzia serrata -- endophytic fungus -- Chaetomium sp. YMF 432 -- metabolites -- acetylcholinesterase inhibitory; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1434648
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: An endophytic fungus, Chaetomium sp. YMF432, was isolated from Huperzia serrata (Thunb. ex Murray) Trev. and subjected to phytochemical investigation based on its special environment. From the extracts of fermentation solid of strain YMF 432, eight compounds including 1- O -methylemodin (1 ), 5-methoxy-2-methyl-3-tricosyl-1, 4-benzoquinone (2 ), 4, 8-dihydroxy-1-tetralone (3 ), (3β, 5α, 6α, 22 E )-3-hydroxy-5, 6-epoxy-7-one-8(14), 22-dien-ergosta (4 ), ergosta-4, 6, 8(14), 22-tetraen-3-one (5 ), β-sitostenone (6 ), β-sitosterol (7 ) and (22 E, 24 R )-ergosta-5, 7, 22 -trien-3β-ol (8 ) were obtained. Their structures were elucidated on the basis of their spectroscopic data. These compounds were evaluated for acetylcholinesterase inhibitory activities in vitro . Compounds1, 2, and4 showed moderate acetylcholinesterase inhibitory activities (IC50 from 37.7 ± 1.5 to 370.0 ± 2.9 μM). Abstract :