Quorum sensing inhibitors from marine bacteria Oceanobacillus sp. XC22919. Issue 12 (18th June 2019)

• Record Type: Journal Article
• Authors: Chen, Xiaochun; Chen, Jianwei; Yan, Yinchun; Chen, Su; Xu, Xuewei; Zhang, Huawei; Wang, Hong
• Is Part Of: Natural product research. Volume 33:Issue 12(2019)
• Page Start: 1819
• Page End: 1823
• Publication Date: 2019-06-18
• Subjects: Marine bacteria -- Oceanobacillus sp. XC22919 -- quorum sensing -- quorum sensing inhibitors -- secondary metabolites -- virulence factors -- pathogens; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1437436
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: In this study, three active compounds isolated from Oceanobacillus sp. XC22919 were identified as 2-methyl- N -(2′-phenylethyl) butyramide (1 ), 3-methyl- N -(2′-phenylethyl)-butyramide (2 ) and benzyl benzoate (3 ), and were first reported to exhibit the apparent quorum sensing inhibitory activities against C. violaceum 026 and P. aeruginosa . Compounds1 –3 inhibited violacein production of C. violaceum 026 by 10.5–55.7, 11.2–55.7, and 27.2%–95.7%, respectively, and inhibited pyocyanin production of P. aeruginosa by 1.7–50.8, 39.1–90.7, and 57.2%–98.7%, respectively. The azocasein-degrading proteolytic rates of P. aeruginosa were observed by 13.4–31.5, 13.4–28.8, and 11.3%–21.1%, respectively. With respect to elastase, the range of inhibition of activity of compounds1 –3 was 2.1–30.3, 4.2–18.2, and 8.9%–15.7%, respectively. Compounds1 and3 also showed a concentration-dependent attenuation in biofilm formation, with the maximum of 50.6% inhibition, and 37.7% inhibition at 100 μg/mL, respectively. Abstract :