Acylphloroglucinols as kinase inhibitors from Sargassum nigrifoloides. Issue 7 (3rd July 2019)

• Record Type: Journal Article
• Authors: Jiang, Cheng-Shi; Wang, Yin-Yin; Song, Jin-Tong; Yu, Jin-Hai
• Is Part Of: Journal of Asian natural products research. Volume 21:Issue 7(2019)
• Page Start: 619
• Page End: 626
• Publication Date: 2019-07-03
• Subjects: Sargassum nigrifoloides -- acylphloroglucinols -- Alzheimer's diseases -- CDK5 -- GSK3β; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2018.1463996
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Three new acylphloroglucinols (1 –3 ) and four known biosynthetically related analogs (4 –7 ) were isolated from the ethanol extract of a brown alga Sargassum nigrifoloides . Structures for1 –7 were characterized via detailed spectroscopic analyses especially 2D NMR data. Screening of these compounds in Alzheimer's diseases-related bioassays revealed moderate inhibitory activities against two therapeutically important kinases, CDK5 and GSK3β. A preliminary structure–activity relationship was also discussed. Abstract :