Glutamine addiction: an Achilles heel in esophageal cancers with dysregulation of CDK4/6. (4th July 2019)

• Record Type: Journal Article
• Authors: Qie, Shuo; Diehl, J. Alan
• Is Part Of: Molecular & cellular oncology. Volume 6:Number 4(2019)
• Publication Date: 2019-07-04
• Subjects: Glutamine-addiction -- cyclin D1 -- glutaminase -- CDK4/6 inhibitor -- acquired resistance; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2019.1610257
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Understanding and overcoming resistance to cyclin-dependent kinase 4/6 (CDK4/6) inhibitors will be challenging. Recent work reveals that dysregulation of F-Box Protein 4 (FBXO4)-Cyclin D1 axis leads to mitochondrial dysfunction and drives glutamine-addiction in esophageal squamous cell carcinoma. This metabolism feature makes these tumors susceptible to combined treatment with glutaminase (GLS) inhibitor and metformin even when resisting to CDK4/6 inhibitors.