Lignans, flavonoids and coumarins from Viola philippica and their α-glucosidase and HCV protease inhibitory activities. Issue 11 (3rd June 2019)

• Record Type: Journal Article
• Authors: Wang, Ya-Li; Zhang, Lin; Li, Meng-Yan; Wang, Li-Wei; Ma, Chao-Mei
• Is Part Of: Natural product research. Volume 33:Issue 11(2019)
• Page Start: 1550
• Page End: 1555
• Publication Date: 2019-06-03
• Subjects: Viola philippica -- lignan -- coumarin -- flavonoids -- α-glucosidase -- HCV protease; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1423305
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two lignans including a new one, five flavonoids and five coumarins were isolated from the whole plant of Viola philippica (synonymised as Viola yedoensis Makino). The new compound was structurally determined as (7 R, 8 S, 8′ S ) -3, 3′-dimethoxy- 4, 4′, 9-trihydroxy- 7, 9′-epoxy-8, 8′-lignan 9-O-rutinoside by analysis of its NMR, MS and CD spectroscopic data. The known compounds were characterised by comparing their NMR and MS data with those reported. Among the known compounds, 5-hydroxy-4′-methoxyflavone-7-O- rutinoside, 6, 7-di-O-β-D- glucopyranosylesculetin, and 7 R, 8 S -dihydrodehydrodiconiferyl alcohol 4-O-β-D- glucopyranoside were isolated and identified from this genus for the first time. Of these compounds, 5-hydroxy-4′-methoxyflavone-7-O-rutinoside and (7 R, 8 S, 8′ S ) -3, 3′-dimethoxy- 4, 4′, 9-trihydroxy- 7, 9′-epoxy-8, 8′-lignan 9-O-rutinoside were potently active against α-glucosidase, while the two dimeric coumarins, 5, 5′-bi (6, 7-dihydroxycoumarin) and 6, 6′, 7, 7′-tetrahydroxy-5, 8′-bicoumarin potently inhibited HCV protease. Abstract :