A mild synthesis of substituted 1, 8-naphthyridines. Issue 11 (10th May 2019)

• Record Type: Journal Article
• Authors: Anderson, Edward C.; Sneddon, Helen F.; Hayes, Christopher J.
• Is Part Of: Green chemistry. Volume 21:Issue 11(2019)
• Page Start: 3050
• Page End: 3058
• Publication Date: 2019-05-10
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c9gc00408d
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : A mild synthesis of substituted 1, 8-naphthyridines from 2-aminonicotinaldehyde is described. Abstract : A greener method for the synthesis of substituted 1, 8-naphthyridines has been developed, which is supported by reaction metric analysis. Using 2-aminonicotinaldehyde as a starting material with a variety of carbonyl reaction partners, the Friedländer reaction can be performed with high yield using water as the reaction solvent. Divergent reactivity was seen when using acrolein, and an alternative method was developed to give access to 2-vinyl-1, 8-naphthyridine in high yield, and an assessment of addition reactions to 2-vinyl-1, 8-naphthyridine was performed.