Polymerization induced phase separation as a generalized methodology for multi-layered hydrogel tubes. Issue 22 (14th May 2019)

• Record Type: Journal Article
• Authors: Rong, Mingming; Ma, Shuanhong; Lin, Peng; Cai, Meirong; Zheng, Zijian; Zhou, Feng
• Is Part Of: Journal of materials chemistry. Volume 7:Issue 22(2019)
• Page Start: 3505
• Page End: 3511
• Publication Date: 2019-05-14
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c9tb00185a
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Herein, we report a conceptually chemical strategy to facilitate the fabrication of layered hydrogel tubes based on the polymerization-induced phase separation mechanism. Abstract : Herein, we report a conceptually chemical strategy to facilitate the fabrication of layered hydrogel tubes based on the polymerization-induced phase separation mechanism. In a typical case, a high purity iron wire is immersed into a sodium alginate (SA) saturated 2-hydroxyethyl methacrylate (HEMA) monomer solution to perform Surface Catalytically Initiated Radical Polymerization (SCIRP), followed by Ca 2+ post-crosslinking. Subsequently, the successful removal of the iron wire template enables the formation of a hollow PHEMA/SA–Ca 2+ layered hydrogel tube. The layered hydrogel tubes can be prepared with tunable sizes, good tensile strength, perfusable 3D complex structure and minimal cytotoxicity. Multi-layered hydrogel tubes can be obtained as well on the basis of monomers diffusion and re-initiation mechanism, which may address the demands for tissue manufacturing. Finally, the bioactivity of the PHEMA/SA–Ca 2+ layered hydrogel tube is proved by the surface adhesion and proliferation of two types of cells-NIH3T3 and PAECs on the inner side of the layered hydrogel tubes.