Albumin enhances PTX delivery ability of dextran NPs and therapeutic efficacy of PTX for colorectal cancer. Issue 22 (9th May 2019)

• Record Type: Journal Article
• Authors: Zhang, Xinyu; Zhang, Ruhe; Huang, Jun; Luo, Moucheng; Chen, Xuewen; Kang, Yang; Wu, Jun
• Is Part Of: Journal of materials chemistry. Volume 7:Issue 22(2019)
• Page Start: 3537
• Page End: 3545
• Publication Date: 2019-05-09
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c9tb00181f
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : The nanoassemblies of Dex6k –BSA–PTX and the pH-responsive drug release for anti-tumor applications in vivo . Abstract : To enhance the drug delivery capability of polysaccharides, a novel strategy was designed utilizing protein as a new party to assist the encapsulation and release of PTX. Herein, the BSA–PTX complex was first prepared, and aldehyde-dextran was then successfully cross-linked with BSA–PTX to obtain pH-sensitive Dex6k –BSA–PTX nanoparticles via the Schiff base reaction. With a size of 150 nm and high drug loading, the Dex6k –BSA–PTX NPs significantly prolonged the blood half-life of PTX and could be passively targeted to tumor tissues, with a significant inhibition of the growth of tumor cells in vivo and in vitro .