Recent progress in photochemical radical di- and mono-fluoromethylation. Issue 22 (14th May 2019)

• Record Type: Journal Article
• Authors: Koike, Takashi; Akita, Munetaka
• Is Part Of: Organic & biomolecular chemistry. Volume 17:Issue 22(2019)
• Page Start: 5413
• Page End: 5419
• Publication Date: 2019-05-14
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c9ob00734b
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Di- and mono-fluoromethyl radicals can be easily accessed by photochemical protocols. Abstract : Recently, photoinduced radical difluoromethylation has emerged as a step-economical synthetic method of CHF2 -containing compounds. In this article, difluoromethylation of alkenes, isonitriles and aryl bromides promoted by photoredox catalysis is described together with a non-catalytic photoinduced system. Representative reactions will be discussed for each highlighted difluoromethylating reagent. In addition, related monofluoromethylation with their corresponding monofluoromethylating reagents is also discussed.