Glucose regulation by modified boronic acid-sulfobetaine zwitterionic nanogels – a non-hormonal strategy for the potential treatment of hyperglycemia. Issue 21 (21st May 2019)

• Record Type: Journal Article
• Authors: GhavamiNejad, Amin; Lu, Brian; Giacca, Adria; Wu, Xiao Yu
• Is Part Of: Nanoscale. Volume 11:Issue 21(2019)
• Page Start: 10167
• Page End: 10171
• Publication Date: 2019-05-21
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c9nr01687b
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : We synthesized a new glucose-responsive nanogel and demonstrated its potential as a non-hormonal treatment strategy for regulating blood glucose level. Abstract : We have introduced a non-hormonal hyperglycemia treatment strategy by using an injectable glucose-responsive boronic acid- zwitterionic nanogel. The synthesized system, similar to an artificial liver, is capable of storing/releasing glucose at high/low blood glucose concentrations. In vivo performance revealed that the injection of the nanogels can effectively regulate blood glucose in type 1 diabetic rats for at least 6 hours.