Decreased Phosphorylation and Increased Methionine Oxidation of α-Synuclein in the Methionine Sulfoxide Reductase A Knockout Mouse. (28th December 2010)

• Record Type: Journal Article
• Authors: Oien, Derek B.; Carrasco, Gonzalo A.; Moskovitz, Jackob
• Other Names: Bitan Gal Academic Editor.
• Is Part Of: Journal of amino acids. Volume 2011(2011)
• Publication Date: 2010-12-28
• Subjects: Amino acids -- Periodicals; Amino Acids; Amino acids; Electronic journals; Periodical; Periodicals; 612.015756
• DOI: 10.4061/2011/721094
• Languages: English
• ISSNs: 2090-0404

Abstract

Abstract : Previously, we have showed that overexpression of methionine-oxidized α -synuclein in methionine sulfoxide reductase A (MsrA) null mutant yeast cells inhibits α -synuclein phosphorylation and increases protein fibrillation. The current studies show that ablation of mouse MsrA gene caused enhanced methionine oxidation of α -synuclein while reducing its own phophorylation levels, especially in the hydrophobic cell-extracted fraction. These data provide supportive evidence that a compromised MsrA function in mammalian brain may cause enhanced pathologies associated with altered α -synuclein oxidation and phosphorylation levels.