Chromatin, DNA structure and alternative splicing. Issue 22 (18th August 2015)

• Record Type: Journal Article
• Authors: Nieto Moreno, Nicolás; Giono, Luciana E.; Cambindo Botto, Adrián E.; Muñoz, Manuel J.; Kornblihtt, Alberto R.
• Is Part Of: FEBS letters. Volume 589:Issue 22(2015)
• Page Start: 3370
• Page End: 3378
• Publication Date: 2015-08-18
• Subjects: Alternative splicing -- RNA polymerase II elongation -- Chromatin structure -- Non-B DNA; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1016/j.febslet.2015.08.002
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Coupling of transcription and alternative splicing via regulation of the transcriptional elongation rate is a well‐studied phenomenon. Template features that act as roadblocks for the progression of RNA polymerase II comprise histone modifications and variants, DNA‐interacting proteins and chromatin compaction. These may affect alternative splicing decisions by inducing pauses or decreasing elongation rate that change the time‐window for splicing regulatory sequences to be recognized. Herein we discuss the evidence supporting the influence of template structural modifications on transcription and splicing, and provide insights about possible roles of non‐B DNA conformations on the regulation of alternative splicing.