Internal Peptide Late‐Stage Diversification: Peptide‐Isosteric Triazoles for Primary and Secondary C(sp3)−H Activation. (5th December 2017)

• Record Type: Journal Article
• Authors: Bauer, Michaela; Wang, Wei; Lorion, Mélanie M.; Dong, Chuan; Ackermann, Lutz
• Is Part Of: Angewandte Chemie. Volume 130:Number 1(2018)
• Page Start: 209
• Page End: 213
• Publication Date: 2017-12-05
• Subjects: Aminosäuren -- Arylierungen -- Palladium -- Peptide -- Triazole; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201710136
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Secondary C(sp 3 )−H arylations were accomplished by palladium catalysis with triazoles as peptide bond isosteres. The unique power of this approach is highlighted by the possibility of achieving secondary C(sp 3 )−H functionalizations on terminal peptides as well as the unprecedented positional‐selective C(sp 3 )−H functionalization of internal peptide positions, setting the stage for modular peptide late‐stage diversification.