Biomarkers for Detection and Monitoring of B16 Melanoma in Mouse Urine and Feces. (23rd February 2015)

• Record Type: Journal Article
• Authors: Sever, Aviv; Abd elkadir, Amir; Matana, Yosef; Gopas, Jacob; Zeiri, Yehuda
• Other Names: Scholler Nathalie Academic Editor.
• Is Part Of: Journal of biomarkers. Volume 2015(2015)
• Publication Date: 2015-02-23
• Subjects: Biochemical markers -- Periodicals; Biomarkers; Biochemical markers; Periodicals; Electronic journals; Periodicals; Electronic journals; 611.01816
• DOI: 10.1155/2015/841245
• Languages: English
• ISSNs: 2090-8660

Abstract

Abstract : Melanoma is the most malignant type of skin cancer. Early detection of melanoma is thus critical for patient prognosis and survival. At present, examination by a skilled dermatologist followed by biopsy of suspicious lesions is the diagnostic gold standard. The aim of the present study was to examine an alternative and noninvasive method for the diagnosis of melanoma at an early stage. We identified and compared the volatile organic compounds (VOCs) in mouse urine and feces, before and after a subcutaneous injection of B16 melanoma cells. We identified a total of 16 VOCs in urine and 13 VOCs in feces that could serve as potential biomarkers. Statistical analysis significantly discriminated between the cancer and control groups. These results should be validated in a larger-scale animal study, after which a study could be designed in patients to develop a melanoma biomarker.