Detection of potentially novel paramyxovirus and coronavirus viral RNA in bats and rats in the Mekong Delta region of southern Viet Nam. (18th April 2017)

• Record Type: Journal Article
• Authors: Berto, A.; Anh, P. H.; Carrique‐Mas, J. J.; Simmonds, P.; Van Cuong, N.; Tue, N. T.; Van Dung, N.; Woolhouse, M. E.; Smith, I.; Marsh, G. A.; Bryant, J. E.; Thwaites, G. E.; Baker, S.; Rabaa, M. A.
• Other Names: Kiet Bach Tuan investigator.; Boni Maciej F. investigator.; Phu Bui Duc investigator.; Campbell James I investigator.; Hung Dang Manh investigator.; Huong Dang Thao investigator.; Oanh Dang Tram investigator.; Day Jeremy N. investigator.; Van Tan Dinh investigator.; van Doorn H. Rogier investigator.; Han Duong An investigator.; Farrar Jeremy J investigator.; Trang Hau Thi Thu investigator.; Nghia Ho Dang Trung investigator.; Long Hoang Bao investigator.; Van Duong Hoang investigator.; Thu Huynh Thi Kim investigator.; Cuong Lam Chi investigator.; Hung Manh investigator.; Phuong Thanh investigator.; Phuc Thi investigator.; Phuong Thi investigator.; Luat Xuan investigator.; Ha Luu Thi Thu investigator.; Van Chuong Ly investigator.; Loan Mai Thi Phuoc investigator.; Nadjm Behzad investigator.; Bao Ngo Thanh investigator.; Tu Nguyen Canh investigator.; Thuan Nguyen Dac investigator.; Dong Nguyen investigator.; Chuyen Nguyen Khac investigator.; An Nguyen Ngoc investigator.; Vinh Nguyen Ngoc investigator.; Hung Nguyen Quoc investigator.; Dung Nguyen Thanh investigator.; Minh Nguyen Thanh investigator.; Binh Nguyen Thi investigator.; Tham Nguyen Thi Hong investigator.; Tien Nguyen Thi Hong investigator.; Chuc Nguyen Thi Kim investigator.; Le Ngoc Nguyen Thi investigator.; Ha Nguyen Thi Lien investigator.; Lien Nguyen Thi Nam investigator.; Diep Nguyen Thi Ngoc investigator.; Nhung Nguyen Thi investigator.; Chau Nguyen Thi Song investigator.; Chi Nguyen Thi Yen investigator.; Trinh Nguyen Thieu investigator.; Van Nguyen Thu investigator.; Van Hung Nguyen investigator.; Van Kinh Nguyen investigator.; Van Minh Hoang Nguyen investigator.; Van My Nguyen investigator.; Van Thang Nguyen investigator.; Van Thanh Nguyen investigator.; Van Vinh Chau Nguyen investigator.; Van Xang Nguyen investigator.; My Pham Ha investigator.; Khoa Pham Thi Minh investigator.; Tam Pham Thi Thanh investigator.; Van Lao Pham investigator.; Van Minh Pham investigator.; Van Be Bay Phan investigator.; Rahman Motiur investigator.; Thompson Corinne investigator.; Ngan Ta Thi Dieu investigator.; Nhu Tran Do Hoang investigator.; Chau Tran Hoang Minh investigator.; Toan Tran Khanh investigator.; Phuc Tran My investigator.; Hong Tran Thi Kim investigator.; Dung Tran Thi Ngoc investigator.; Thanh Tran Thi Thanh investigator.; Minh Tran Thi Thuy investigator.; Nguyen Tran Thua investigator.; Hien Tran Tinh investigator.; Tri Trinh Quang investigator.; Hien Vo Be investigator.; Tai Vo Nhut investigator.; Cuong Vo Quoc investigator.; Phat Voong Vinh investigator.; Huong Vu Thi Lan investigator.; Hang Vu Thi Ty investigator.; Wertheim Heiman investigator.; Bogaardt Carlijn investigator.; Brierley Liam investigator.; Chase‐Topping Margo investigator.; Ivens Al investigator.; Lu Lu investigator.; Rambaut Andrew investigator.; Woolhouse Mark investigator.; Cotten Matthew investigator.; Oude Munnink Bas B. investigator.; Kellam Paul investigator.; Phan My Vu Tra investigator.; van der Hoek Lia investigator.; Deijs Martin investigator.; Jebbink Maarten F. investigator.; Farsani Seyed Mohammad Jazaeri investigator.; Saylors Karen investigator.; Wolfe Nathan investigator.;
• Is Part Of: Zoonoses and public health. Volume 65:Number 1(2018)
• Page Start: 30
• Page End: 42
• Publication Date: 2017-04-18
• Subjects: bats -- coronavirus -- paramyxovirus -- rats -- Viet Nam -- zoonotic viruses; Zoonoses -- Periodicals; Public health -- Periodicals; 636.0896959
• DOI: 10.1111/zph.12362
• Languages: English
• ISSNs: 1863-1959

Abstract

Summary: Bats and rodents are being increasingly recognized as reservoirs of emerging zoonotic viruses. Various studies have investigated bat viruses in tropical regions, but to date there are no data regarding viruses with zoonotic potential that circulate in bat and rat populations in Viet Nam. To address this paucity of data, we sampled three bat farms and three wet markets trading in rat meat in the Mekong Delta region of southern Viet Nam. Faecal and urine samples were screened for the presence of RNA from paramyxoviruses, coronaviruses and filoviruses. Paramyxovirus RNA was detected in 4 of 248 (1%) and 11 of 222 (4.9%) bat faecal and urine samples, respectively. Coronavirus RNA was detected in 55 of 248 (22%) of bat faecal samples; filovirus RNA was not detected in any of the bat samples. Further, coronavirus RNA was detected in 12 of 270 (4.4%) of rat faecal samples; all samples tested negative for paramyxovirus. Phylogenetic analysis revealed that the bat paramyxoviruses and bat and rat coronaviruses were related to viruses circulating in bat and rodent populations globally, but showed no cross‐species mixing of viruses between bat and rat populations within Viet Nam. Our study shows that potentially novel variants of paramyxoviruses and coronaviruses commonly circulate in bat and rat populations in Viet Nam. Further characterization of the viruses and additional human and animal surveillance is required to evaluate the likelihood of viral spillover and to assess whether these viruses pose a risk to human health.