Domino Oxidative Esterification of 2‐Oxo Alcohol Using 2‐Iodoxybenzoic Acid/I2: A Route to Synthesize α‐Ketoester. Issue 28 (26th July 2018)

• Record Type: Journal Article
• Authors: Sundaravelu, Nallappan; Chakraborty, Ankush; Sekar, Govindasamy
• Is Part Of: ChemistrySelect. Volume 3:Issue 28(2018)
• Page Start: 8167
• Page End: 8170
• Publication Date: 2018-07-26
• Subjects: domino synthesis -- iodine catalyt -- keto ester -- oxidation -- 2-oxo alcohol; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201800941
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: An efficient metal‐free methodology for the synthesis of α‐ketoesters has been developed using α ‐hydroxy ketones and alcohols which follows domino alcohol oxidation and esterification reaction sequence. This methodology shows wide range of substrate scopes to bestow the products in excellent yield. A gram scale synthesis has been carried out to show the practical utility of the protocol. Abstract : This domino oxidative esterification methodology provides transition metal free synthesis of keto ester using mild oxidant. Commercially available and stable starting material afford this methodology more convenient. Practical utility of this methodology has demonstrated with 28 examples. A gram scale synthesis variation yielded the same yield