Nickel‐Catalyzed Asymmetric [2+2] Cycloaddition Reaction of Hetero‐Bicyclic Alkenes with Internal Alkynes. Issue 17 (3rd July 2018)

• Record Type: Journal Article
• Authors: Qin, Hongyu; Chen, Jingchao; Li, Kangkui; He, Zhenxiu; Zhou, Yongyun; Fan, Baomin
• Is Part Of: Chemistry, an Asian journal. Volume 13:Issue 17(2018)
• Page Start: 2431
• Page End: 2434
• Publication Date: 2018-07-03
• Subjects: alkynes -- asymmetric catalysis -- azabenzonorbornadiene -- cycloaddition -- oxabenzonorbornadiene; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201800492
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract: Enantioselective [2+2] cycloaddition reaction of azabenzonorbornadienes and oxabenzonorbornadienes with internal alkynes has been enabled by a catalyst system comprising Ni(COD)2 and ( R )‐SIPHOS‐Ph‐Mor. This transformation represents the first asymmetric [2+2] cycloaddition reaction of azabenzonorbornadienes with internal alkynes, providing a straightforward method to prepare four‐membered carbocycles. Abstract : Enantioselective [2+2] cycloaddition reaction of azabenzonorbornadienes and oxabenzonorbornadienes with internal alkynes has been accomplished using Ni(COD)2 /( R )‐SIPHOS‐Ph‐Mor catalytic system. This transformation represents a straightforward method to prepare four‐membered carbocycles.