Efficient Aliphatic C−H Bond Oxidation Catalyzed by Manganese Complexes with Hydrogen Peroxide. Issue 17 (30th March 2018)

• Record Type: Journal Article
• Authors: Wang, Wenfang; Xu, Daqian; Sun, Qiangsheng; Sun, Wei
• Is Part Of: Chemistry, an Asian journal. Volume 13:Issue 17(2018)
• Page Start: 2458
• Page End: 2464
• Publication Date: 2018-03-30
• Subjects: bioinspired catalysis -- C−H activation -- homogeneous catalysis -- manganese -- oxidation; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201800068
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract: A tetradentate nitrogen ligand containing a benzimidazole ring and an electron‐rich pyridine ring was developed, the resulting manganese complex exhibited good activity in the C−H oxidation of simple alkanes. In particular, cyclic aliphatic alkanes were transformed into ketones in very good yields (up to 89 %) by using environmentally benign H2 O2 as the terminal oxidant. This protocol was also applied successfully in benzylic C−H oxidation, giving the corresponding ketones with very good selectivities. In addition, tertiary C−H bond oxidation of complex molecules by the manganese complex showed potential utility for assembling alcohols with good selectivity in late‐stage chemical synthesis. Abstract : C−H bond oxidation : A tetradentate nitrogen ligand containing a benzimidazole and a pyridine ring was developed and the resulting manganese complex served as an efficient catalyst in the oxidation of cyclic aliphatic alkanes, as well as benzylic C−H.