Hepatitis E in southern Vietnam: Seroepidemiology in humans and molecular epidemiology in pigs. (9th June 2017)

• Record Type: Journal Article
• Authors: Berto, A.; Pham, H. A.; Thao, T. T. N.; Vy, N. H. T.; Caddy, S. L.; Hiraide, R.; Tue, N. T.; Goodfellow, I.; Carrique‐Mas, J. J.; Thwaites, G. E.; Baker, S.; Boni, M. F.
• Other Names: Kiet Bach Tuan investigator.; Kiet Bach Tuan investigator.; Bryant Juliet E investigator.; Phu Bui Duc investigator.; Campbell James I investigator.; Hung Dang Manh investigator.; Huong Dang Thao investigator.; Oanh Dang Tram investigator.; Day Jeremy N investigator.; Van Tan Dinh investigator.; van Doorn H. Rogier investigator.; Han Duong An investigator.; Farrar Jeremy J investigator.; Trang Hau Thi Thu investigator.; Nghia Ho Dang Trung investigator.; Long Hoang Bao investigator.; Van Duong Hoang investigator.; Thu Huynh Thi Kim investigator.; Cuong Lam Chi investigator.; Hung Manh investigator.; Phuong Thanh investigator.; Phuc Thi investigator.; Phuong Thi investigator.; Luat Xuan investigator.; Ha Luu Thi Thu investigator.; Van Chuong Ly investigator.; Loan Mai Thi Phuoc investigator.; Nadjm Behzad investigator.; Bao Ngo Thanh investigator.; Hoa Ngo Thi investigator.; Tu Nguyen Canh investigator.; Thuan Nguyen Dac investigator.; Dong Nguyen investigator.; Chuyen Nguyen Khac investigator.; An Nguyen Ngoc investigator.; Vinh Nguyen Ngoc investigator.; Hung Nguyen Quoc investigator.; Dung Nguyen Thanh investigator.; Minh Nguyen Thanh investigator.; Binh Nguyen Thi investigator.; Tham Nguyen Thi Hong investigator.; Tien Nguyen Thi Hong investigator.; Chuc Nguyen Thi Kim investigator.; Le Ngoc Nguyen Thi investigator.; Ha Nguyen Thi Lien investigator.; Lien Nguyen Thi Nam investigator.; Diep Nguyen Thi Ngoc investigator.; Nhung Nguyen Thi investigator.; Chau Nguyen Thi Song investigator.; Chi Nguyen Thi Yen investigator.; Trinh Nguyen Thieu investigator.; Van Nguyen Thu investigator.; Van Cuong Nguyen investigator.; Van Hung Nguyen investigator.; Van Kinh Nguyen investigator.; Van Minh Hoang Nguyen investigator.; Van My Nguyen investigator.; Van Thang Nguyen investigator.; Van Thanh Nguyen investigator.; Van Vinh Chau Nguyen investigator.; Van Xang Nguyen investigator.; My Pham Ha investigator.; Khoa Pham Thi Minh investigator.; Tam Pham Thi Thanh investigator.; Van Lao Pham investigator.; Van Minh Pham investigator.; Van Be Bay Phan investigator.; Rabaa Maia A investigator.; Rahman Motiur investigator.; Thompson Corinne investigator.; Ngan Ta Thi Dieu investigator.; Nhu Tran Do Hoang investigator.; Chau Tran Hoang Minh investigator.; Toan Tran Khanh investigator.; Phuc Tran My investigator.; Hong Tran Thi Kim investigator.; Dung Tran Thi Ngoc investigator.; Thanh Tran Thi Thanh investigator.; Minh Tran Thi Thuy investigator.; Nguyen Tran Thua investigator.; Hien Tran Tinh investigator.; Tri Trinh Quang investigator.; Hien Vo Be investigator.; Tai Vo Nhut investigator.; Cuong Vo Quoc investigator.; Phat Voong Vinh investigator.; Huong Vu Thi Lan investigator.; Hang Vu Thi Ty investigator.; Wertheim Heiman investigator.; Bogaardt Carlijn investigator.; Chase‐Topping Margo investigator.; Ivens Al investigator.; Lu Lu investigator.; Ngyuen Dung investigator.; Rambaut Andrew investigator.; Simmonds Peter investigator.; Woolhouse Mark investigator.; Cotten Matthew investigator.; Oude Munnink Bas B. investigator.; Kellam Paul investigator.; Phan My Vu Tra investigator.; van der Hoek Lia investigator.; Deijs Martin investigator.; Jebbink Maarten F. investigator.; Farsani Seyed Mohammad Jazaeri investigator.; Saylors Karen investigator.; Wolfe Nathan investigator.;
• Is Part Of: Zoonoses and public health. Volume 65:Number 1(2018)
• Page Start: 43
• Page End: 50
• Publication Date: 2017-06-09
• Subjects: hepatitis E virus -- human -- pigs -- prevalence -- seroprevalence -- Vietnam -- zoonosis; Zoonoses -- Periodicals; Public health -- Periodicals; 636.0896959
• DOI: 10.1111/zph.12364
• Languages: English
• ISSNs: 1863-1959

Abstract

Summary: Viral pathogens account for a significant proportion of the burden of emerging infectious diseases in humans. The Wellcome Trust‐Vietnamese Initiative on Zoonotic Infections (WT‐VIZIONS) is aiming to understand the circulation of viral zoonotic pathogens in animals that pose a potential risk to human health. Evidence suggests that human exposure and infections with hepatitis E virus (HEV) genotypes (GT) 3 and 4 results from zoonotic transmission. Hypothesising that HEV GT3 and GT4 are circulating in the Vietnamese pig population and can be transmitted to humans, we aimed to estimate the seroprevalence of HEV exposure in a population of farmers and the general population. We additionally performed sequence analysis of HEV in pig populations in the same region to address knowledge gaps regarding HEV circulation and to evaluate if pigs were a potential source of HEV exposure. We found a high prevalence of HEV GT3 viral RNA in pigs (19.1% in faecal samples and 8.2% in rectal swabs) and a high HEV seroprevalence in pig farmers (16.0%) and a hospital‐attending population (31.7%) in southern Vietnam. The hospital population was recruited as a general‐population proxy even though this particular population subgroup may introduce bias. The detection of HEV RNA in pigs indicates that HEV may be a zoonotic disease risk in this location, although a larger sample size is required to infer an association between HEV positivity in pigs and seroprevalence in humans.