Systemic Role for Vitamin D in the Treatment of Psoriasis and Metabolic Syndrome. (5th June 2011)

• Record Type: Journal Article
• Authors: Fu, Lisa Wenyang; Vender, Ronald
• Other Names: Naldi Luigi Academic Editor.
• Is Part Of: Dermatology research and practice. Volume 2011(2011)
• Publication Date: 2011-06-05
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; Skin -- Diseases -- Treatment -- Periodicals; 616.5005
• DOI: 10.1155/2011/276079
• Languages: English
• ISSNs: 1687-6105

Abstract

Abstract : The novel discovery of the systemic role of vitamin D in the modulation of the immune system especially the Type 1 helper T cell (Th1) pathway reveals its potential for treating Th1 inflammatory diseases. Psoriasis has been recently established to be a systemic disease centered on inflammation and involvement of cytokines of the Th1 pathway. There is an increased prevalence of metabolic syndrome in patients with psoriasis. Metabolic syndrome also involves a proinflammatory state. This paper proposes the idea of the potential use of oral vitamin D to treat psoriasis and metabolic syndrome concurrently. We propose there is merit in more clinical trials investigating the use of vitamin D to treat both psoriasis and metabolic syndrome through its anti-inflammatory effects. On application to psoriasis management and prognosis, the goal is to decrease the risk for cardiovascular disease and decrease disease morbidity and mortality.