Mammalian Fibroblast Cells Show Strong Preference for Laser-Generated Hybrid Amorphous Silicon-SiO2 Textures. Issue 1 (26th January 2017)

• Record Type: Journal Article
• Authors: Colpitts, Candace; Ektesabi, Amin M.; Wyatt, Rachael A.; Crawford, Bryan D.; Kiani, Amirkianoosh
• Is Part Of: Journal of applied biomaterials & functional materials. Volume 15:Issue 1(2017)
• Page Start: 84
• Page End: 92
• Publication Date: 2017-01-26
• Subjects: Bioactivity -- Fibroblast -- Laser materials processing -- Laser pulses -- Nanofibers -- Silicon; Biomedical materials -- Periodicals; Bioengineering -- Periodicals; Biomechanics -- Periodicals; 610.28
• DOI: 10.5301/jabfm.5000327
• Languages: English
• ISSNs: 2280-8000

Abstract

Background: In this study, we investigated a method to produce bioactive hybrid amorphous silicon and silicon oxide patterns using nanosecond laser pulses. Methods: Microscale line patterns were made by laser pulses on silicon wafers at different frequencies (25, 70 and 100 kHz), resulting in ablation patterns with frequency-dependent physical and chemical properties. Results: Incubating the laser-treated silicon substrates with simulated body fluid demonstrated that the physicochemical properties of the laser-treated samples were stable under these conditions, and favored the deposition of bone-like apatite. More importantly, while NIH 3T3 fibroblasts did colonize the untreated regions of the silicon wafers, they showed a strong preference for the laser-treated regions, and further discriminated between substrates treated with different frequencies. Conclusions: Taken together, these data suggest that laser materials processing of silicon-based devices is a promising avenue to pursue in the production of biosensors and other bionic devices.