Theoretical Implications of a Pre-Erythrocytic Plasmodium vivax Vaccine for Preventing Relapses. Issue 4 (April 2017)

• Record Type: Journal Article
• Authors: White, Michael; Amino, Rogerio; Mueller, Ivo
• Is Part Of: Trends in parasitology. Volume 33:Issue 4(2017:Apr.)
• Page Start: 260
• Page End: 263
• Publication Date: 2017-04
• Subjects: Plasmodium vivax -- malaria -- vaccine -- relapse -- hypnozoite; Parasitology -- Periodicals; Parasitology -- Periodicals; Biology -- Periodicals; Parasitology; Biology; Parasitologie -- Périodiques; Online resources; 571.999
• DOI: 10.1016/j.pt.2016.12.011
• Languages: English
• ISSNs: 1471-4922

Abstract

Abstract : Preventing malaria infection through vaccination requires preventing every sporozoite inoculated by mosquito bite: a major challenge for Plasmodium falciparum . Plasmodium vivax sporozoites consist of tachysporozoites causing primary infection and bradysporozoites leading to relapses. We hypothesise that a candidate P. vivax vaccine with low efficacy against primary infection may substantially reduce transmission by preventing relapses.