Pyrrolidines and Piperidines by Ligand‐Enabled Aza‐Heck Cyclizations and Cascades of N‐(Pentafluorobenzoyloxy)carbamates. Issue 18 (22nd March 2018)

• Record Type: Journal Article
• Authors: Hazelden, Ian R.; Carmona, Rafaela C.; Langer, Thomas; Pringle, Paul G.; Bower, John F.
• Is Part Of: Angewandte Chemie international edition. Volume 57:Issue 18(2018)
• Page Start: 5124
• Page End: 5128
• Publication Date: 2018-03-22
• Subjects: aza-Heck reaction -- cascade reactions -- N-heterocycles -- palladium; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201801109
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Ligand‐enabled aza‐Heck cyclizations and cascades of N ‐(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non‐biased 6‐ exo aza‐Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidines. Abstract : Direct and flexible : Ligand‐enabled aza‐Heck cyclizations and cascades of N ‐(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non‐biased 6‐ exo aza‐Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidines.