Influence of dental materials on cells of the equine periodontium. (3rd November 2017)

• Record Type: Journal Article
• Authors: Ringeisen, H.; Pöschke, A.; Krähling, B.; Schröck, C.; Stoll, M.; Vogelsberg, J.; Failing, K.; Staszyk, C.
• Is Part Of: Equine veterinary journal. Volume 50:Number 3(2018)
• Page Start: 363
• Page End: 369
• Publication Date: 2017-11-03
• Subjects: horse -- periodontal disease -- equine periodontal fibroblasts -- dental materials -- biocompatibility -- gene expression; Horses -- Diseases -- Periodicals; 636.108905
• DOI: 10.1111/evj.12768
• Languages: English
• ISSNs: 0425-1644

Abstract

Summary: Background: Therapy for equine periodontal disease can include filling of the periodontal pockets and widened interproximal spaces. Recommended dental materials are generally adopted from human dentistry. Objectives: To evaluate the biocompatibility of dental materials for equine periodontal fillings in vitro. Study design: In vitro experiments. Methods: Four different dental materials (PeriCare ®, Provicol ®, Calxyl ® and Honigum) were tested on equine periodontal fibroblasts. Possible cytotoxic effects were assessed microscopically and by MTT assay, and the expression of inflammatory marker genes was measured by qRT‐PCR. Results: PeriCare ® and Provicol ® had no effects on the cells, whereas Honigum and Calxyl ® were associated with severe cytotoxic effects. Main limitations: The results of this in vitro study need to be confirmed by clinical studies. Conclusions: Before adapting dental materials from human dentistry, it is crucial to initially test them in a specific equine model.