Primary CNS Lymphoma Arising from the 4th Ventricle: A Case Report and Review of the Literature. (10th April 2019)

• Record Type: Journal Article
• Authors: Brozovich, Ava; Ewing, Donald; Burns, Ethan; Hatcher, Courtney; Acosta, Gonzalo; Khan, Usman; Chung, Betty; Samuel, Leena; Randhawa, Jasleen; Pingali, Sai Ravi
• Other Names: Buchanich Jeanine M. Academic Editor.
• Is Part Of: Case reports in oncological medicine. Volume 2019(2019)
• Publication Date: 2019-04-10
• Subjects: Oncology -- Periodicals; Tumors -- Periodicals; Oncology -- Case studies -- Periodicals; Neoplasms; Oncology; Tumors; Electronic journals; Periodicals; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.994
• DOI: 10.1155/2019/2671794
• Languages: English
• ISSNs: 2090-6706

Abstract

Abstract : A 65-year-old male with a history of ischemic strokes, seizures, and subarachnoid hemorrhage presented with a 4-week history of progressive diplopia, vertigo, nausea, and vomiting. Magnetic resonance imaging (MRI) revealed a2.5 × 1.8 × 1.7 cm posterior fossa mass arising from the roof of the 4 th ventricle extending into the cerebellar vermis. Posterior fossa craniotomy with stereotactic biopsy confirmed a locally invasive diffuse large B-cell lymphoma (DLBCL). Primary central nervous system lymphoma (PCNSL) arising from the 4 th ventricle is a rare extranodal manifestation of non-Hodgkin lymphoma (NHL), with few cases documented in the literature. Review of available cases lends support that lymphoma arising from the 4 th ventricle has a variable clinical presentation, occurs most commonly in immunocompetent males, and should be on the differential of any immunocompetent adult presenting with a posterior fossa mass. Optimal treatment modalities are based largely on phase 2 clinical trials, and recommended guidelines regardless of anatomic location should be adhered to.