Decreased Risk of Squamous Cell Carcinoma of the Head and Neck in Users of Nonsteroidal Anti-Inflammatory Drugs. (2nd June 2010)

• Record Type: Journal Article
• Authors: Ahmadi, Neda; Goldman, Radoslav; Seillier-Moiseiwitsch, Françoise; Noone, Anne-Michelle; Kosti, Ourania; Davidson, Bruce J.
• Other Names: Bradley Patrick James Academic Editor.
• Is Part Of: International journal of otolaryngology. Volume 2010(2010)
• Publication Date: 2010-06-02
• Subjects: Otolaryngology -- Periodicals; Otorhinolaryngologic Diseases; Otolaryngology; Electronic journals; Periodicals; Periodicals; 617.51
• DOI: 10.1155/2010/424161
• Languages: English
• ISSNs: 1687-9201

Abstract

Abstract : We evaluated the chemopreventive effect of nonsteroidal anti-inflammatory drug (NSAID) use in head and neck squamous cell carcinomas (HNSCC) by conducting a case-control study based on the administration of a standardized questionnaire to 71 incident HNSCC cases and same number of healthy controls. NSAID use was associated with a 75% reduction in risk of developing HNSCC. A significant risk reduction was noted in association with frequency of NSAID use. Restricting the analysis to aspirin users revealed a significant 90% reduction in risk of developing HNSCC. This study provides evidence for a significant reduction in the risk of developing HNSCC in users of NSAIDs, and specifically aspirin users.