Multiparity activates interferon pathways in peritoneal adipose tissue and decreases susceptibility to ovarian cancer metastasis in a murine allograft model. (28th December 2017)

• Record Type: Journal Article
• Authors: Loughran, Elizabeth A.; Phan, Ryan C.; Leonard, Annemarie K.; Tarwater, Laura; Asem, Marwa; Liu, Yueying; Yang, Jing; Klymenko, Yuliya; Johnson, Jeff; Shi, Zonggao; Hilliard, Tyvette S.; Blumenthaler, Marielle; Leevy, Matthew; Ravosa, Matthew J.; Stack, M. Sharon
• Is Part Of: Cancer letters. Volume 411(2018)
• Page Start: 74
• Page End: 81
• Publication Date: 2017-12-28
• Subjects: Ovarian cancer metastasis -- Parity -- Interferons (IFNs) -- Murine age-matched model of parity -- Adipose tissue; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2017.09.028
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Ovarian cancer is the fifth leading cause of cancer deaths in U.S. women and the deadliest gynecologic malignancy. This lethality is largely due to the fact that most cases are diagnosed at metastatic stages of the disease when the prognosis is poor. Epidemiologic studies consistently demonstrate that parous women have a reduced risk of developing ovarian cancer, with a greater number of births affording greater protection; however little is known about the impact of parity on ovarian cancer metastasis. Here we report that multiparous mice are less susceptible to ovarian cancer metastasis in an age-matched syngeneic murine allograft model. Interferon pathways were found to be upregulated in healthy adipose tissue of multiparous mice, suggesting a possible mechanism for the multiparous-related protective effect against metastasis. This protective effect was found to be lost with age. Based on this work, future studies exploring therapeutic strategies which harness the multiparity-associated protective effect demonstrated here are warranted. Highlights: Parous women have reduced risk of developing ovarian cancer. The impact of parity on ovarian cancer metastasis is unknown. Multi-parous mice are less susceptible to ovarian cancer metastasis. Upregulation of interferon pathways may contribute to the protective effect of parity.