Multiple perianal ulcers due to suppositories. (24th July 2018)

• Record Type: Journal Article
• Authors: Savoia, Francesco; Sechi, Andrea; Tabanelli, Michela; Zago, Silvia; Leuzzi, Miriam; Baraldi, Carlotta; Patrizi, Annalisa
• Is Part Of: Australasian journal of dermatology. Volume 60:Number 1(2019)
• Page Start: 50
• Page End: 52
• Publication Date: 2018-07-24
• Subjects: caffeine -- indomethacin -- perianal ulcers -- prochlorperazine dimaleate -- suppositories; Dermatology -- Periodicals; Dermatology -- Australasia -- Periodicals; 616.5005
• DOI: 10.1111/ajd.12888
• Languages: English
• ISSNs: 0004-8380

Abstract

Abstract: We report a case of long‐standing inexplicable perianal ulcers. After exclusion of an inflammatory, infectious or neoplastic origin, a thorough personal history revealed that for many years the patient had been using analgesic suppositories containing indomethacin, caffeine, and prochlorperazine dimaleate, four to five times a week, for migraine. On stopping the suppositories, there was complete healing within 12 weeks. We hypothesize that vasoconstriction and vascular damage were the pathogenetic mechanisms behind the perianal ulcers.