Chiral 1, 3, 2‐Diazaphospholenes as Catalytic Molecular Hydrides for Enantioselective Conjugate Reductions. (6th March 2018)

• Record Type: Journal Article
• Authors: Miaskiewicz, Solène; Reed, John H.; Donets, Pavel A.; Oliveira, Caio C.; Cramer, Nicolai
• Is Part Of: Angewandte Chemie. Volume 130:Number 15(2018)
• Page Start: 4103
• Page End: 4106
• Publication Date: 2018-03-06
• Subjects: Asymmetrische Katalyse -- Diazaphospholene -- Organokatalyse -- Phosphor -- Reduktionen; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201801300
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Secondary 1, 3, 2‐diazaphospholenes have a polarized P−H bond and are emerging as molecular hydrides. Herein, a class of chiral, conformationally restricted methoxy‐1, 3, 2‐diazaphospholene catalysts is reported. We demonstrate their catalytic potential in asymmetric 1, 4‐reductions of α, β‐unsaturated carbonyl derivatives, including enones, acyl pyrroles, and amides, which proceeded in enantioselectivities of up to 95.5:4.5 e.r.