Dermal uptake of phthalates from clothing: Comparison of model to human participant results. (9th December 2016)

• Record Type: Journal Article
• Authors: Morrison, G. C.; Weschler, C. J.; Bekö, G.
• Is Part Of: Indoor air. Volume 27:Number 3(2017:Jun.)
• Page Start: 642
• Page End: 649
• Publication Date: 2016-12-09
• Subjects: absorption -- exposure -- fabric -- model -- skin -- semivolatile organic compounds; Indoor air pollution -- Periodicals; Sick building syndrome -- Periodicals; Ventilation -- Periodicals; 613.5
• DOI: 10.1111/ina.12354
• Languages: English
• ISSNs: 0905-6947

Abstract

Abstract: In this research, we extend a model of transdermal uptake of phthalates to include a layer of clothing. When compared with experimental results, this model better estimates dermal uptake of diethylphthalate and di‐n‐butylphthalate (DnBP) than a previous model. The model predictions are consistent with the observation that previously exposed clothing can increase dermal uptake over that observed in bare‐skin participants for the same exposure air concentrations. The model predicts that dermal uptake from clothing of DnBP is a substantial fraction of total uptake from all sources of exposure. For compounds that have high dermal permeability coefficients, dermal uptake is increased for (i) thinner clothing, (ii) a narrower gap between clothing and skin, and (iii) longer time intervals between laundering and wearing. Enhanced dermal uptake is most pronounced for compounds with clothing–air partition coefficients between 10 4 and 10 7 . In the absence of direct measurements of cotton cloth–air partition coefficients, dermal exposure may be predicted using equilibrium data for compounds in equilibrium with cellulose and water, in combination with computational methods of predicting partition coefficients.