The association between MICA/MICB polymorphism and respiratory syncytial virus infection in children. (18th September 2017)

• Record Type: Journal Article
• Authors: Luo, Q.; Guo, X.; Peng, S.; Luo, W.; Tian, F.; Yu, P.; Zou, Y.
• Is Part Of: International journal of immunogenetics. Volume 44:Number 6(2017:Dec.)
• Page Start: 328
• Page End: 336
• Publication Date: 2017-09-18
• Subjects: gene polymorphism -- MICA alleles -- MICB alleles -- respiratory syncytial virus -- respiratory tract infection; Immunogenetics -- Periodicals; 571.9648
• DOI: 10.1111/iji.12338
• Languages: English
• ISSNs: 1744-3121

Abstract

Summary: MICA/MICB gene polymorphisms are related to several cancers and infectious diseases, but there are no reports on the association between MICA/MICB gene polymorphisms and respiratory syncytial virus (RSV) infection. To clarify the association between MICA/MICB gene polymorphisms and infection of RSV in children, we collected fresh blood samples from paediatric patients with and without pneumonia after RSV infection. The MICA/MICB alleles were characterized by PCR sequence‐specific primers (PCR‐SSP) and PCR sequence‐based genotyping (PCR‐SBT), and then, the frequency of the MICA/MICB alleles and haplotypes was calculated. The results showed that the frequencies of MICA*002:01 and MICA‐A9 in RSV‐infected patients were significantly lower than in controls (9% vs. 20%, pc = 0.04). The allele frequency of MICA*002:01 in pneumonia patients (8%) and nonpneumonia patients (9%) was significantly lower than in controls (20%, pc = 0.02). MICA*002:01‐MICB*008 (Δrel = 0.616), MICA*009‐MICB*016 (Δrel = 0.506), and MICA*045‐MICB*014 (Δrel = 0.700) showed linkage disequilibrium in patients infected with RSV. The haplotype frequency of MICA*002:01‐MICB*005:02 in RSV‐infected patients was significantly lower than in controls (10% vs. 16%, pc = 0.033). In conclusion, allele MICA*002:01/A9 and haplotype MICA*002:01‐MICB*005:02 were negatively associated with RSV respiratory tract infections.