Total Synthesis of (−)‐Enigmazole A. (24th March 2018)
- Record Type:
- Journal Article
- Title:
- Total Synthesis of (−)‐Enigmazole A. (24th March 2018)
- Main Title:
- Total Synthesis of (−)‐Enigmazole A
- Authors:
- Sakurai, Keisuke
Sasaki, Makoto
Fuwa, Haruhiko - Abstract:
- Abstract: Total synthesis of (−)‐enigmazole A, a marine macrolide natural product with cytotoxic activity, has been accomplished. The tetrahydropyran moiety was constructed by means of a domino olefin cross‐metathesis/intramolecular oxa‐Michael addition of a δ‐hydroxy olefin. After coupling of advanced intermediates, the macrocycle was formed through gold‐catalyzed rearrangement of a propargylic benzoate, followed by ring‐closing metathesis of the resultant α, β‐unsaturated ketone.
- Is Part Of:
- Angewandte Chemie. Volume 130:Number 18(2018)
- Journal:
- Angewandte Chemie
- Issue:
- Volume 130:Number 18(2018)
- Issue Display:
- Volume 130, Issue 18 (2018)
- Year:
- 2018
- Volume:
- 130
- Issue:
- 18
- Issue Sort Value:
- 2018-0130-0018-0000
- Page Start:
- 5237
- Page End:
- 5240
- Publication Date:
- 2018-03-24
- Subjects:
- Makrocyclen -- Metathese -- Naturstoffe -- Totalsynthesen -- Umlagerungen
Chemistry -- Periodicals
540 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/ange.201801561 ↗
- Languages:
- English
- ISSNs:
- 0044-8249
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0902.000000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 10629.xml