BSA‐IrO2: Catalase‐like Nanoparticles with High Photothermal Conversion Efficiency and a High X‐ray Absorption Coefficient for Anti‐inflammation and Antitumor Theranostics. Issue 32 (12th July 2018)

• Record Type: Journal Article
• Authors: Zhen, Wenyao; Liu, Yang; Lin, Lin; Bai, Jing; Jia, Xiaodan; Tian, Huayu; Jiang, Xiue
• Is Part Of: Angewandte Chemie international edition. Volume 57:Issue 32(2018)
• Page Start: 10309
• Page End: 10313
• Publication Date: 2018-07-12
• Subjects: imaging agents -- iridium -- nanoparticles -- photoacoustic imaging -- phototherapy; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201804466
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Intrinsically integrating precise diagnosis, effective therapy, and self‐anti‐inflammatory action into a single nanoparticle is attractive for tumor treatment and future clinical application, but still remains a great challenge. In this study, bovine serum albumin–iridium oxide nanoparticles (BSA‐IrO2 NPs) with extraordinary photothermal conversion efficiency, good photocatalytic activity, and a high X‐ray absorption coefficient were prepared through one‐step biomineralization. The nanoparticles allow tumor phototherapy and simultaneous photoacoustic/thermal imaging and computed tomography. More importantly, BSA‐IrO2 NPs can also act as a catalase to protect normal cells against H2 O2 ‐induced reactive oxygen pressure and inflammation while significantly enhancing photoacoustic imaging through microbubble‐based inertial cavitation. These remarkable features may open up the exploration iridium‐based nanomaterials in theranostics. Abstract : Pulling out all the stops : Bovine serum albumin–IrO2 nanoparticles (BSA‐IrO2 NPs) with extraordinary photothermal conversion efficiency and catalase‐like activity were prepared by facile biomineralization. The BSA‐IrO2 NPs enable PA/CT/thermal imaging‐guided tumor phototherapy, overcome tumor hypoxia, protect normal cells against H2 O2 ‐induced inflammation, and simultaneously enhance photoacoustic imaging through microbubble‐based inertial cavitation.