Chemical constituents from Sambucus williamsii Hance fruits and hepatoprotective effects in mouse hepatocytes. Issue 17 (2nd September 2018)

• Record Type: Journal Article
• Authors: Kuang, Haixue; Tang, Zhenqiu; Wang, Xinguo; Yang, Bingyou; Wang, Zhibin; Wang, Qiuhong
• Is Part Of: Natural product research. Volume 32:Issue 17(2018)
• Page Start: 2008
• Page End: 2016
• Publication Date: 2018-09-02
• Subjects: Sambucus williamsii Hance -- chemical constituents -- phenylethanoid glycosides -- hepatoprotective effects; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1361948
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Chemical investigation of Chinese folk medicine Sambucus williamsii Hance has resulted in the isolation and characterisation of seventeen compounds from the n -BuOH extract of its fruits, including two new phenylethanoid glycosides and fifteen known compounds. Structures of new compounds were elucidated primarily on the basis of their extensive spectroscopic data including 2D NMR. In addition, the n -BuOH extract from the fruits of S. williamsii was found to show a protective effect on D-galactosamine (D-GalN)-induced cytotoxicity in primary cultured mouse hepatocytes. So the hepatoprotective effects of principal constituents from it were tested by MTT assays. The results showed that Compounds13, 16 and17 displayed hepatoprotective effects. Abstract :