Microbial carbonylation and hydroxylation of 20(R)-panaxadiol by Aspergillus niger. Issue 7 (3rd April 2018)

• Record Type: Journal Article
• Authors: Yan, Bin; Chen, Zhihua; Zhai, Xuguang; Yin, Guibo; Ai, Yafei; Chen, Guangtong
• Is Part Of: Natural product research. Volume 32:Issue 7(2018)
• Page Start: 782
• Page End: 787
• Publication Date: 2018-04-03
• Subjects: Biotransformation -- 20(R)-panaxatriol -- Aspergillus niger -- anti-hepatic fibrosis; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1360887
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: 20( R )-panaxadiol (PD) was metabolised by the fungus Aspergillus niger AS 3.3926 to its C-3 carbonylated metabolite and five other hydroxylated metabolites (1 –6). Their structures were elucidated as 3-oxo-20( R )-panaxadiol (1 ), 3-oxo-7β-hydroxyl- 20( R )-panaxadiol (2 ), 3-oxo-7β, 23α-dihydroxyl-20( R )-panaxadiol (3 ), 3, 12-dioxo- 7β, 23β-dihydroxyl-20( R )-panaxadiol (4 ), 3-oxo-1α, 7β-dihydroxyl-20( R )-panaxadiol (5 ) and 3-oxo-7β, 15β-dihydroxyl-20( R )-panaxadiol (6 ) by spectroscopic analysis. Among them, compounds2 –6 were new compounds. Pharmacological studies revealed that compound6 exhibited significant anti-hepatic fibrosis activity. Abstract :