Ex vivo assessment and in vivo validation of non-invasive stent monitoring techniques based on microwave spectrometry. Issue 1 (December 2018)

• Record Type: Journal Article
• Authors: Gálvez-Montón, Carolina; Arauz-Garofalo, Gianluca; Rodriguez-Leor, Oriol; Soler-Botija, Carolina; Amorós García de Valdecasas, Susana; Gerez-Britos, Flavio; Bayes-Genis, Antoni; O'Callaghan, Juan; Macià, Ferran; Tejada, Javier
• Is Part Of: Scientific reports. Volume 8:Issue 1(2018)
• Page Start: 1
• Page End: 8
• Publication Date: 2018-12
• Subjects: Natural history -- Research -- Periodicals; Biology -- Research -- Periodicals; Physical sciences -- Research -- Periodicals; Earth sciences -- Research -- Periodicals; Environmental sciences -- Research -- Periodicals; 502.85
• DOI: 10.1038/s41598-018-33254-9
• Languages: English
• ISSNs: 2045-2322

Abstract

Abstract Some conditions are well known to be directly associated with stent failure, including in-stent re-occlusion and stent fracture. Currently, identification of these high-risk conditions requires invasive and complex procedures. This study aims to assess microwave spectrometry (MWS) for monitoring stents non-invasively. Preliminaryex vivo data are presented to move toin vivo validation. Fifteen mice were assigned to receive subcutaneous stent implantations (n = 10) or sham operations (n = 5). MWS measurements were carried out at 0, 2, 4, 7, 14, 22, and 29 days of follow-up. Additionally, 5 stented animals were summited to micro-CT analyses at the same time points. At 29 days, 3 animals were included into a stent fracture subgroup and underwent a last MWS and micro-CT analysis. MWS was able to identify stent position and in-stent stenosis over time, also discerning significant differences from baseline measures (P < 0.001). Moreover, MWS identified fractured vs. non-fractured stentsin vivo . Taken together, MWS emerges as a non-invasive, non-ionizing alternative for stent monitoring. MWS analysis clearly distinguished between in-stent stenosis and stent fracture phenomena.