Evasion of Host Defence by Leishmania donovani: Subversion of Signaling Pathways. (7th April 2011)

• Record Type: Journal Article
• Authors: Shadab, Md.; Ali, Nahid
• Other Names: Majumder Hemanta K. Academic Editor.
• Is Part Of: Molecular biology international. Volume 2011(2011)
• Publication Date: 2011-04-07
• Subjects: Molecular biology -- Periodicals; Molecular Biology; Molecular biology; Electronic journals; Periodical; Fulltext; Internet Resources; Periodicals; Periodicals; 572.8
• DOI: 10.4061/2011/343961
• Languages: English
• ISSNs: 2090-2182

Abstract

Abstract : Protozoan parasites of the genus Leishmania are responsible for causing a variety of human diseases known as leishmaniasis, which range from self-healing skin lesions to severe infection of visceral organs that are often fatal if left untreated. Leishmania donovani ( L. donovani ), the causative agent of visceral leishmaniasis, exemplifys a devious organism that has developed the ability to invade and replicate within host macrophage. In fact, the parasite has evolved strategies to interfere with a broad range of signaling processes in macrophage that includes Protein Kinase C, the JAK2/STAT1 cascade, and the MAP Kinase pathway. This paper focuses on how L. donovani modulates these signaling pathways that favour its survival and persistence in host cells.