Response to Long-term Vitamin D Therapy for Bone Disease in Children With Sickle Cell Disease. Issue 6 (August 2018)

• Record Type: Journal Article
• Authors: Williams, Kristen M.; Lee, Margaret T.; Licursi, Maureen; Brittenham, Gary M.; Fennoy, Ilene
• Is Part Of: Journal of pediatric hematology/oncology. Volume 40:Issue 6(2018)
• Publication Date: 2018-08
• Subjects: sickle cell anemia -- bone density -- secondary hyperparathyroidism -- pediatrics -- vitamin D deficiency; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000001155
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : Patients with sickle cell disease (SCD) are at risk for bone fragility from multiple factors including vitamin D deficiency. To date, no studies have evaluated the efficacy and safety of long-term vitamin D therapy for bone disease in children with SCD. We report a cohort of 4 children with SCD found to have severe vitamin D deficiency, secondary hyperparathyroidism, and abnormal bone mineral density treated with monthly high-dose oral cholecalciferol over 2 years. All patients exhibited a positive response to therapy without hypervitaminosis D or hypercalcemia. Further studies are needed to standardize guidelines for optimal vitamin D dosing and prevention of toxicity.