Ziprasidone as Adjunctive Therapy in Severe Bipolar Patients Treated with Clozapine. (7th April 2014)

• Record Type: Journal Article
• Authors: Bartolommei, Natalia; Casamassima, Francesco; Pensabene, Laura; Luchini, Federica; Benvenuti, Antonella; Di Paolo, Antonello; Cosentino, Luca; Mauri, Mauro; Lattanzi, Lorenzo
• Other Names: Beasley C. M. Academic Editor.; Khanna S. Academic Editor.
• Is Part Of: ISRN psychiatry. Volume 2014(2014)
• Publication Date: 2014-04-07
• Subjects: Psychiatry -- Periodicals; Psychology, Pathological -- Periodicals; Mental illness -- Periodicals; Mental Disorders; Psychiatry; Mental illness; Psychiatry; Psychology, Pathological; Electronic journals; Periodical; Fulltext; Internet Resources; Periodicals; Periodicals; 616.89
• DOI: 10.1155/2014/904829
• Languages: English
• ISSNs: 2090-7966

Abstract

Abstract : Aim . To confirm the efficacy and tolerability of ziprasidone as adjunctive therapy in bipolar patients partially responding to clozapine or with persisting negative symptoms, overweight, or with metabolic syndrome. Methods . Eight patients with psychotic bipolar disorder were tested with the BPRS, the HAM-D, and the CGI at T0 and retested after 2 weeks (T1). Plasma clozapine and norclozapine levels and BMI were tested at T0 and T1. Results . Ziprasidone was well tolerated by all the patients. BPRS and HAM-D scores were reduced in all patients. BMI was reduced in patients with a BMI at T0 higher than 25. Plasma levels of clozapine and norclozapine showed an irregular course.