RNA Polymerase II Elongation at the Crossroads of Transcription and Alternative Splicing. (20th September 2011)

• Record Type: Journal Article
• Authors: de la Mata, Manuel; Muñoz, Manuel J.; Alló, Mariano; Fededa, Juan Pablo; Schor, Ignacio E.; Kornblihtt, Alberto R.
• Other Names: Sune Carles Academic Editor.
• Is Part Of: Genetics research international. Volume 2011(2011)
• Publication Date: 2011-09-20
• Subjects: Genetics -- Research -- Periodicals; 576.5072
• DOI: 10.4061/2011/309865
• Languages: English
• ISSNs: 2090-3154

Abstract

Abstract : The elongation phase of transcription lies at the core of several simultaneous and coupled events leading to alternative splicing regulation. Although underestimated in the past, it is at this phase of the transcription cycle where complexes affecting the transcription machinery itself, chromatin structure, posttranscriptional gene regulation and pre-mRNA processing converge to regulate each other or simply to consolidate higher-order complexes and functions. This paper focuses on the multiple processes that take place during transcription elongation which ultimately regulate the outcome of alternative splicing decisions.