The Role of Chronic Inflammation in Obesity-Associated Cancers. (30th May 2013)

• Record Type: Journal Article
• Authors: Ramos-Nino, Maria E.
• Other Names: Balaram P. Academic Editor.; Faraoni I. Academic Editor.; Hunakova L. Academic Editor.; Karakitsos P. Academic Editor.; Luber B. Academic Editor.
• Is Part Of: ISRN oncology. Volume 2013(2013)
• Publication Date: 2013-05-30
• Subjects: Oncology -- Periodicals; Neoplasms; Oncology; Periodicals; 616.994
• DOI: 10.1155/2013/697521
• Languages: English
• ISSNs: 2090-5661

Abstract

Abstract : There is a strong relationship between metabolism and immunity, which can become deleterious under conditions of metabolic stress. Obesity, considered a chronic inflammatory disease, is one example of this link. Chronic inflammation is increasingly being recognized as an etiology in several cancers, particularly those of epithelial origin, and therefore a potential link between obesity and cancer. In this review, the connection between the different factors that can lead to the chronic inflammatory state in the obese individual, as well as their effect in tumorigenesis, is addressed. Furthermore, the association between obesity, inflammation, and esophageal, liver, colon, postmenopausal breast, and endometrial cancers is discussed.