Efficacy and Safety of Daikenchuto for Constipation and Dose-Dependent Differences in Clinical Effects. (5th March 2018)

• Record Type: Journal Article
• Authors: Hirose, Tatsuya; Shinoda, Yasutaka; Kuroda, Ayaka; Yoshida, Aya; Mitsuoka, Machiko; Mori, Kouki; Kawachi, Yuki; Moriya, Akihiro; Tanaka, Kouji; Takeda, Atsuko; Yoshimura, Tomoaki; Sugiyama, Tadashi
• Other Names: Zorena Katarzyna Academic Editor.
• Is Part Of: International journal of chronic diseases. Volume 2018(2018)
• Publication Date: 2018-03-05
• Subjects: Chronic diseases -- Periodicals; Chronic Disease; Chronic diseases; Periodicals; Periodicals; Electronic journals; Fulltext; Internet Resources; Periodicals; 616.044
• DOI: 10.1155/2018/1296717
• Languages: English
• ISSNs: 2356-6981

Abstract

Abstract : Background . Daikenchuto (DKT) is a Kampo medicine used for the treatment of constipation. In this study, we evaluated the effectiveness of DKT against constipation. Patients and Methods. Thirty-three patients administered DKT for constipation were selected and divided into low-dose (7.5 g DKT;n = 22 ) and high-dose (15 g DKT;n = 11 ) groups. We retrospectively evaluated weekly defaecation frequency, side effects, and clinical laboratory data. Results . Median defaecation frequencies after DKT administration (5, 5.5, 5, and 8 for the first, second, third, and fourth weeks, resp.) were significantly higher than that before DKT administration (2) in all 33 cases (P < 0.01 ). One case (3%) of watery stool, one case of loose stools (3%), and no cases of abdominal pain (0%) were observed. Median defaecation frequencies in the high-dose group (7 and 9) were significantly higher than those in the low-dose group (4 and 3) in the first (P = 0.0133 ) and second (P = 0.0101 ) weeks, respectively. There was no significant change in clinical laboratory values. Conclusion . We suggest that DKT increases defaecation frequency and is safe for treating constipation.